procainamide HCl
procainamide hydrochloride
CAS: 614-39-1
Molecular Formula: C13H22ClN3O
procainamide HCl - Names and Identifiers
| Name | procainamide hydrochloride |
| Synonyms | PROCAINAMIDE HCL procainamide HCl PROCAINAMIDE HYDROCHLORIDE procainamide hydrochloride Procainamidi Hydrochloridum PROCAINE AMIDE HYDROCHLORIDE 4-AMINO-N-[2'-(DIETHYLAMINO)ETHYL]BENZAMIDE HCL 4-AMINO-N-(2-DIETHYLAMINOETHYL)BENZAMIDE HYDROCHLORIDE N-(2-DIETHYLAMINOETHYL)-4-AMINOBENZAMIDE HYDROCHLORIDE 4-amino-n-(2-diethylaminoethyl)benzamide hydrochloride 2-[[(4-aminophenyl)-oxomethyl]amino]ethyl-diethylammonium 4-AMINOBENZOIC ACID 2-DIETHYLAMINOETHYLAMIDE HYDROCHLORIDE |
| CAS | 614-39-1 |
| EINECS | 210-381-7 |
| InChI | InChI=1/C13H21N3O.2ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);2*1H |
procainamide HCl - Physico-chemical Properties
| Molecular Formula | C13H22ClN3O |
| Molar Mass | 271.79 |
| Density | 1.2027 (rough estimate) |
| Melting Point | 165-168°C |
| Water Solubility | soluble |
| Solubility | H2O: soluble1g/10 mL, clear, greenish-yellow |
| Appearance | Powder |
| Color | White to slightly yellow |
| Merck | 13,7845 |
| BRN | 3729517 |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive/Air Sensitive |
| Refractive Index | 1.6330 (estimate) |
| Physical and Chemical Properties | Melting point 165-170°C water-soluble soluble |
| Use | Antiarrhythmic drugs, suitable for ventricular arrhythmias |
procainamide HCl - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | CV2295000 |
| HS Code | 29242990 |
procainamide HCl - Standard
Authoritative Data Verified Data
This product is N-[(2-diethylamino) ethyl]-4-aminobenzamide hydrochloride. The content of C13H21N30 • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
procainamide HCl - Trait
Authoritative Data Verified Data
- This product is white to light yellow crystalline powder; Odorless; With hygroscopicity.
- This product is soluble in water, soluble in ethanol, slightly soluble in chloroform, and slightly soluble in ether.
melting point
The melting point of this product (General 0612) is 165~169 ℃.
Last Update：2022-01-01 15:35:12
procainamide HCl - Differential diagnosis
Authoritative Data Verified Data
- take 0.lg of this product, add 5ml of water, add 1 drop of ferric chloride test solution and 1 drop of concentrated hydrogen peroxide solution, slowly heat to boiling, the solution is purplish red, then turn dark brown to brown black.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 398).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:35:13
procainamide HCl - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 5.0~6.5.
loss on drying
take this product, dry to constant weight at 105 ℃, weight loss shall not exceed 0.3% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 15:35:14
procainamide HCl - Content determination
Authoritative Data Verified Data
take this product about 0.55g, precision weighing, according to the permanent stop titration method (General 0701), with sodium nitrite titration solution (0.lmol/L) titration. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 27.18mg of C13H21N30. Hc1.
Last Update：2022-01-01 15:35:14
procainamide HCl - Category
Authoritative Data Verified Data
local anesthetic.
Last Update：2022-01-01 15:35:14
procainamide HCl - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:35:14
procainamide HCl - Procainamide hydrochloride tablets
Authoritative Data Verified Data
This product contains procainamide hydrochloride (C13H21N30 • HC1) should be the label amount of 95.0% ~ 105.0%.
trait
This product is white to yellowish or sugar-coated.
identification
- take an appropriate amount of the fine powder of this product, add water to shake to dissolve the hydrochloride, filter, take the filtrate and add water to make a solution containing 5ug of hydrochloride, there is an absorption maximum at a wavelength of 0401 nm as determined by UV-Vis spectrophotometry (general rule).
- take an appropriate amount of the fine powder of this product (about 0.lg of the equivalent of procainine hydrochloride), add 5ml of water and 0.5ml of dilute hydrochloric acid, shake to dissolve the procainine hydrochloride, filter, the filtrate showed identification reaction of aromatic first amine (General 0301).
- The above remaining filtrate shows the reaction of chloride identification (1) (General 0301).
examination
- dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (9-100) as the dissolution medium, the speed is rpm, operate according to law, after 75 minutes, take 10ml of solution to filter, take 2ml of filtrate, put it in 50ml measuring flask, add 0.1 mol / L sodium hydroxide solution diluted to the scale, shake, according to UV-visible spectrophotometry (General 0401), at the wavelength of 273nm absorbance, the elution amount of each tablet was calculated as the absorption coefficient of C13H21N30 · HCL was 605. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, put it in a 100ml measuring flask, add 50ml of water, shake to dissolve the hydrochloric acid, dilute to the scale with water, shake, stand, take 20ml of supernatant, according to the permanent stop titration method (General rule 0701), with sodium nitrite titration solution (0.lmol /L titration. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 27.18mg of C13H21N30. HCI.
category
Same as procainamide hydrochloride.
specification
0.25g
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:35:15
procainamide HCl - Procainamide hydrochloride injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of procainine hydrochloride. The content of procainine hydrochloride (C13H21N30 • HC1) shall be between 95.0% and 105.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
- take an appropriate amount of this product, and add water to make a solution containing 5ug of hydrochloric acid in 1 ml. According to UV-visible spectrophotometry (General 0401), there is maximum absorption at 280nm wavelength.
- This product is aromatic first amine identification reaction (General rule 0301) and chloride identification (1) reaction (General rule 0301).
examination
- the pH value should be 3.5-6.0 (General rule 06 3 1).
- pyrogen to take this product, according to the law (General 1142), the dose of rabbit body weight per lkg injection 0.5, should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take 5ml of this product accurately, add 40ml of water and 10ml of hydrochloric acid solution (1-2), quickly boil, immediately cool to room temperature, follow the permanent stop titration method (General rule 0701), with sodium nitrite titration solution (0.lmol/L) titration. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 27.18mg of C13H21N30. Hc1.
category
Same as procainamide hydrochloride.
specification
(l )lml:0.1g ( 2) 2ml: 0.2g (3)5ml:0.5g(4) 10ml:lg
storage
light shielding, closed storage.
Last Update：2022-01-01 15:35:16
procainamide HCl - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | procainamide hydrochloride is a chemical drug substance that is similar to quinidine and is a typical membrane stabilizer for ventricular arrhythmias, it can also be used to prevent arrhythmia in patients with atrial arrhythmia and myocardial infarction. |
| Use | procainamide hydrochloride is a Class I a antiarrhythmic drug. It can prolong the atrial refractory period, reduce the atrioventricular conductivity and myocardial automaticity, but the inhibition of myocardial contractility is weaker than that of quinidine. It is suitable for paroxysmal tachycardia, frequent premature beats (good for ventricular premature beats), atrial fibrillation and atrial flutter, and is often used alternately with quinidine. |
| preparation | procainamide was originally synthesized using 4-nitrobenzoyl chloride as the starting material, in the following decades, many new synthetic methods appeared, such as 4-nitrobenzoic acid and diethylaminoethylamine as starting materials. However, the yield of these synthetic routes is low, and the product is difficult to purify, which leads to industrial difficulties in production and is difficult to apply to large-scale industrial production. |
| Use | antiarrhythmic. Similar to quinidine, it is a typical membrane stabilizer. It is suitable for ventricular arrhythmia, atrial arrhythmia and prevention of arrhythmia in patients with myocardial infarction. antiarrhythmic drug, suitable for ventricular arrhythmia |
| production method | p-nitrobenzoyl chloride is condensed with diethylaminoethylamine to give P-nitro-N-(2-diethylaminoethyl) benzamide (nitrocarinamine), and then the catalytic hydrogenation of procaine Amine, and then using hydrochloric acid to salt is the goods. |
Last Update：2024-04-09 15:16:51
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Spot supply
Product Name: Procainamide hydrochloride Visit Supplier Webpage Request for quotationCAS: 614-39-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Procainamide hydrochloride Request for quotation
CAS: 614-39-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 614-39-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
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